Epidemiology in African Americans
Certain characteristics put some people at higher risk for multiple myeloma.
These risk factors include1,2:
African Americans are often diagnosed at a younger age than White Americans.3
Since younger African American patients have a higher incidence of MGUS, a precursor to multiple myeloma, the chances of developing the disease are increased for this population.2* African Americans are 2 to 3 times more likely to have MGUS compared to White patients,† and are nearly 2 times more likely to progress to multiple myeloma.5,6‡§
Note: According to a retrospective, population-based, cohort study, investigating obesity and the risk of progressing from MGUS to multiple myeloma.
African Americans Have Different Cytogenetics in Multiple Myeloma
Several studies looked at common subtypes of myeloma that are used to determine risk.7-10 African Americans had a higher frequency of translocation 11;14 and a lower frequency of deletion 17p.7,9,10 This could indicate a better prognosis among African Americans compared with White Americans.
Even though their risk profile may result in better prognoses, they experience higher mortality, suggesting that poorer outcomes are a function of disparity of care.10
MGUS=Monoclonal gammopathy of undetermined significance.